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KEGG : Acute myeloid leukemia

Pathway Class : Human Diseases; Cancers
Pathway Description : Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases,  the transcription factors themselves are mutated.(obtained from KEGG 10/09/11)

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2)Reference List
Reference ID Source
16236521Pubmed
12563308Pubmed
16146838Pubmed
12951584Pubmed
16642045Pubmed
15625120Pubmed
11721960Pubmed
12468433Pubmed
17554387Pubmed
16352814Pubmed